Paris Saint-Germain vs Manchester United is the standout tie of the Champions League last 16 after the draw was made by UEFA in Nyon, Switzerland on Monday lunchtime.
The two-legged affair will reunite Lionel Messi and Cristiano Ronaldo as their respective new clubs are paired together in the Champions League for the third time in four seasons.
Liverpool will face Red Bull Salzburg again, having met the Austrian side in the 2019/20 group stage, with Real Madrid to meet a Benfica side that was complicit in knocking out Barcelona.
Holders Chelsea came away with arguably the most favourable draw they could have hoped for in Lille, while Bayern Munich have been matched with Atletico Madrid.
It was a random draw so each seeded group winner was paired against an unseeded group runner-up, while country protection also remained in place. Clubs who qualified from the same group were also kept apart for this round.
2021/22 Champions League last 16 draw in full
Benfica vs Real Madrid
Villarreal vs Manchester City
Atletico Madrid vs Bayern Munich
Red Bull Salzburg vs Liverpool
Inter vs Ajax
Sporting CP vs Juventus
Chelsea vs Lille
PSG vs Manchester United