Osimhen will be gunning for his second outing and first Europa goal as Napoli face home side, Real Sociedad.
The 21-year old made his Europa League, debut playing for 66 minutes and firing blanks as Napoli fell 0-1 at home against AZ Alkmaar in their first group game last week
Chukwueze will also be in action as Villarreal go on the road trip against Qarabag after played all 90 minutes in the 5-3 home win against Sivasspor last week.
Iheanacho on his part, will be gunning for his second Europa League goal for Leicester City as The Foxes play away against AEK Athens.
Aribo, and his Nigeria teammate, Leon Balogun, will star for Rangers as they play host to Polish side, Lech Poznan.
Aribo played the last 23 minutes while Balogun starred for 90 minutes in the Gers’ 2-0 win against Standard Liege last week.
Nigeria international, Olanrewaju Kayode, will be targeting a winning outing with Sivasspor as they play host to Maccabi Tel Aviv.
Ramon Azeez’s hopes of Europa League debut for Granada remains a doubt as they host PAOK Thessaloniki.
The 25-year old is nursing a muscle fiber tear injury which has kept him out of action in recent times. He is yet to star in any European competition.